Contributor: Gordon K. Klintworth
Both lenses are usually involved in microphakia. Relative to the lens diameter the anteroposterior axis of the lens is increased. The anterior pole of the lens may be in apposition to the posterior surface of the cornea. Microphakia can be transmitted as an autosomal recessive disorder. Sometimes microphakia is an isolated anomaly, but it may also accompany an abnormal anterior chamber angle, ectopia lentis et pupillae, a persistent tunica vasculosa lentis and megalocornea. Such associations may be manifestations of Marfan syndrome and Weill-Marchesani syndrome. An uncomplicated microphakia is caused by an arrest in the lens development at about the fifth or sixth month of development when it is normally spherical.