Contributors: Richard J Grostern and Daniel M.
Goodpasture disease (Goodpasture syndrome, lung purpura with nephritis, pulmonary hemorrhage and glomerulonephritis, hemorrhagic pneumonia and nephritis, hemorrhagic pulmonary-renal syndrome, pulmonary hemosiderosis with glomerulonephritis, and anti-glomerular basement membrane antibody-mediated nephritis with pulmonary hemorrhage) is a syndrome consisting of a triad of glomerulonephritis, lung hemorrhage, and antibodies to the basement membrane of glomeruli. Most reported patients have been young adult males with an average age of onset of 20-30 years. More recently with the wide application of assays for anti-glomerular basement membrane antibody it has become apparent that any age or either sex may be affected. Patients from 4 to 80 years of age have been described. Left untreated most patients will develop renal failure, eventually requiring dialysis. Severe bouts of recurring hemoptysis, some life threatening, are typical, however recovery from pulmonary complications can be complete. In most cases the ocular findings are similar to what is seen in uncontrolled hypertension and renal disease, namely retinal hemorrhages [hemorrhage - retina] and exudates.